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| Henry Liu,Lisa Sangkum,Geoffrey Liu,Michael Green,Marilyn Li,Alan Kaye.Journal of Biomedical Research,2016,30(5):/span> |
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| Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes |
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Received:February 16, 2016Revised:March 18, 2016
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DOI：10.7555/JBR.30.20160024
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Keywords：epinephrine, angiogenesis, gene expression, cardiomyocytes, angiopoietin-2, neuregulin 1, plasminogen activator inhibitor-1, SPARC-related modular calcium-binding protein
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| Author |
Institution |
| Henry Liu |
Department of Anesthesiology & Perioperative Medicine, Drexel University College of Medicine, Hahnemann University Hospital, Philadelphia, PA 19102, USA |
| Lisa Sangkum |
Department of Anesthesiology & Perioperative Medicine, Drexel University College of Medicine, Hahnemann University Hospital, Philadelphia, PA 19102, USA |
| Geoffrey Liu |
Department of Anesthesiology & Perioperative Medicine, Drexel University College of Medicine, Hahnemann University Hospital, Philadelphia, PA 19102, USA |
| Michael Green |
Department of Anesthesiology & Perioperative Medicine, Drexel University College of Medicine, Hahnemann University Hospital, Philadelphia, PA 19102, USA |
| Marilyn Li |
Division of Genomic Diagnostics, Dept. of Pathology & Laboratory Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA 19104, USA |
| Alan Kaye |
Department of Anesthesiology, LSUHSC-New Orleans, New Orleans, LA 70112, USA |
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| Abstract ： |
| Epinephrine is often used for the treatment of patients with heart failure, low cardiac output and cardiac arrest. It can acutely improve hemodynamic parameters; however, it does not seem to improve longer term clinical outcomes. Therefore, we hypothesized that epinephrine may induce unfavorable changes in gene expression of cardiomyocyte. Thus, we investigated effects of epinephrine exposure on the mediation or modulation of gene expression of cultured cardiomyocytes at a genome-wide scale. Our investigation revealed that exposure of cardiomyocytes to epinephrine in an in vitro environment can up-regulate the expression of angiopoietin-2 gen (+ 2.1 times), and down-regulate the gene expression of neuregulin 1 ( C 3.7 times), plasminogen activator inhibitor-1 ( C 2.4 times) and SPARC-related modular calcium-binding protein-2 ( C 4.5 times). These changes suggest that epinephrine exposure may induce inhibition of angiogenesis-related gene expressions in cultured rat cardiomyocytes. The precise clinical significance of these changes in gene expression, which was induced by epinephrine exposure, warrants further experimental and clinical investigations.
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