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| Jianming Wu,Ling Li.Journal of Biomedical Research,2016,30(5):/span> |
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| Autoantibodies in Alzheimer's disease: potential biomarkers, pathogenic roles, and therapeutic implications |
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Received:September 15, 2015
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DOI：10.7555/JBR.30.20150131
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Keywords：Alzheimer's disease, autoimmune, autoantibody, biomarker, pathogenesis, immunotherapy
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Grant Program：
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| Author |
Institution |
| Jianming Wu |
Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA |
| Ling Li |
Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA |
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| Abstract ： |
| Alzheimer's disease (AD) is a prevalent and debilitating neurodegenerative disorder in the elderly. The etiology of AD has not been fully defined and currently there is no cure for this devastating disease. Compelling evidence sug-gests that the immune system plays a critical role in the pathophysiology of AD. Autoantibodies against a variety- of molecules have been associated with AD. The roles of these autoantibodies in AD, however, are not well -understood.This review attempts to summarize recent findings on these autoantibodies and explore their potential as diagnostic/ prognostic biomarkers for AD, their roles in the pathogenesis of AD, and their implications in the development of effective immunotherapies for AD.
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