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| Lotte Jacobs,Lutgarde Thijs,Yu Jin,Faiez Zannad,Alexandre Mebazaa,Philippe Rouet,Florence Pinet,Christophe Bauters,Burkert Pieske,Andreas Tomaschitz,Mamas Mamas,Javier Diez,Kenneth McDonald,John G F Cleland,Hans-Peter Brunner-La Rocca,Stephane Heymans,Roberto Latini,Serge Masson,Peter Sever,Christian Delles,Stuart Pocock,Timothy Collier,Tatiana Kuznetsova,Jan A Staessen,On behalf of the Heart ‘omics’ in AGEing (HOMAGE) investigators.Journal of Biomedical Research,2014,28(5):/span> |
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| Heart ‘omics’ in AGEing (HOMAGE): design, research objectives and characteristics of the common database |
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Received: March 08, 2014Revised: March 31, 2014
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DOI：10.7555/JBR.28.20140045
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Keywords：left ventricle, heart failure, heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, population science, morbidity, mortality
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Grant Program：
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| Author |
Institution |
| Lotte Jacobs |
Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium |
| Lutgarde Thijs |
Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium |
| Yu Jin |
Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium |
| Faiez Zannad |
Centre d'Investigation Clinique Pierre Drouin and U 961, Hypertension and Heart Failure Unit, Institut Lourrain du Coeur et des Vaisseaux, Inserm, Nancy, France |
| Alexandre Mebazaa |
Department of Anesthesiology and Critical Care Medicine, InsermUMR-S942, Ho? pital Lariboisie`re, Universite′ Paris Diderot, Paris, France |
| Philippe Rouet |
Equipe obe′ site′ et insuffisance cardiaque, Universite′ UPS, Inserm I2MC, UMR 1048, Toulouse, France |
| Florence Pinet |
Inserm, U744, CHRU, Lille, France |
| Christophe Bauters |
Inserm, U744, CHRU, Lille, France |
| Burkert Pieske |
Department of Cardiology, Medical University Graz, Austria |
| Andreas Tomaschitz |
Department of Cardiology, Medical University Graz, Austria |
| Mamas Mamas |
Crdiovascular Institute, University of Manchester, Manchester, UK |
| Javier Diez |
Division of Cardiovascular Sciences, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain |
| Kenneth McDonald |
Heart Failure Unit, St Vincent's University Hospital, University College Dublin, Dublin, Ireland |
| John G F Cleland |
Department of Cardiology, University of Hull, UK |
| Hans-Peter Brunner-La Rocca |
Department of Cardiology, Maastricht University Medical Centre, Netherlands |
| Stephane Heymans |
Center for Heart Failure Research, Department of Cardiology, Maastricht University, Netherlands |
| Roberto Latini |
Department of Cardiovascular Research, IRCCS - Istituto di Ricerche Farmacologiche ‘‘Mario Negri’’, Milan, Italy |
| Serge Masson |
Department of Cardiovascular Research, IRCCS - Istituto di Ricerche Farmacologiche ‘‘Mario Negri’’, Milan, Italy |
| Peter Sever |
International Center for Circulatory Health, Imperial College London, UK |
| Christian Delles |
Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Center, University of Glasgow, Glasgow, UK |
| Stuart Pocock |
London School of Hygiene and Tropical Medicine, London, UK |
| Timothy Collier |
London School of Hygiene and Tropical Medicine, London, UK |
| Tatiana Kuznetsova |
Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium |
| Jan A Staessen |
Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium |
| On behalf of the Heart ‘omics’ in AGEing (HOMAGE) investigators |
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| Abstract ： |
| Heart failure is common in older people and its prevalence is increasing. The Heart ‘omics’ in AGEing (HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure. A large clinical database, based on (1) prospective population studies or (2) cross-sectional, prospective studies or randomized controlled trials (RCTs) of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising ‘omics’-based biomarkers to identify the risk of developing heart failure and/or comorbidities. Population studies, patient cohorts and RCTs are eligible for inclusion in the common database, if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk factors. Currently, the HOMAGE database includes 43,065 subjects, from 20 studies in eight European countries, including healthy subjects from three population studies in France, Belgium and Italy (n=7,124), patients with heart failure (n=4,312) from four cohorts in the UK, Spain and Switzerland and patients at high risk for cardiovascular disease (n=31,629) in 13 cohorts. It is anticipated that more partners will join the consortium and enlarge the pooled data. This large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.
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