 CiteULikeView Full TextView/Add CommentDownload reader
| Xiaozheng Zhong,Xiaoyu Li,Lingling Qian,Yiming Xu,Yan Lu,Jing Zhang,Nan Li,Xudong Zhu,Jingjing Ben,Qing Yang,Qi Chen.Journal of Biomedical Research,2012,26(5):/span> |
|
| Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats |
|
|
|
|
|
DOI：10.7555/JBR.26.20110124
|
|
Keywords：glycine, glycine receptor 2 subunit, ischemia reperfusion, apoptosis, cardiomyocytes
|
|
Grant Program：
|
| Author |
Institution |
| Xiaozheng Zhong |
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu , China |
| Xiaoyu Li |
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu , China;State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu , China. |
| Lingling Qian |
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu , China |
| Yiming Xu |
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu , China. |
| Yan Lu |
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu , China |
| Jing Zhang |
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu , China. |
| Nan Li |
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu , China |
| Xudong Zhu |
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu , China. |
| Jingjing Ben |
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu , China |
| Qing Yang |
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu , China |
| Qi Chen |
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu , China;State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu , China. |
|
Hits:1269
|
|
Download times:34
|
|
|
| Abstract ： |
| Glycine is a well-documented cytoprotective agent. However, whether it has a protective effect against myocardial ischemia-reperfusion injury in vivo is still unknown. By using an open-chest anesthetized rat model, we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats. The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%, respectively, in glycine-treated rats. The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment. Importantly, administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium, which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase, as well as the Fas ligand. These results suggest that glycine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis.
|
|
|
Close
|
|
|
|
|
|
Archives