• Journal of Biomedical Research is a peer reviewed open access journal dedicated to publishing high-quality research in all areas of the biological and medical sciences.
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Current Issue Journal of Biomedical Research--2017, 31(3)
PERSPECTIVE
Chinese medical service and medical education in urgent need of reform in the context of public welfare-based medical reform
Jinfan Wang

J Biomed Res 2017;31(3): .
REVIEW ARTICLES
Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers
Anam Akhtar,Scarlet Xiaoyan Wang,Lucy Ghali,Celia Bell,Xuesong Wen
Since arsenic trioxide was first approved as the front line therapy for acute promyelocytic leukemia 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation. However, the clinical successes of arsenic trioxide in treating hematological cancers have not...more>>
J Biomed Res 2017;31(3): .
The interaction between the Wnt/β-catenin signaling cascade and PKG activation in cancer
Kevin Lee,Gary A Piazza
The activation of the Wnt/β-catenin signaling cascade has been well studied and documented in colorectal cancer (CRC). The long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to reduce the incidence and risk of death from CRC in numerous epidemiological studies. The NSAID ...more>>
J Biomed Res 2017;31(3): .
Perioperative “remote” acute lung injury: recent update
Zhaosheng Jin,Ka Chun Suen,Daqing Ma
Perioperative acute lung injury (ALI) is a syndrome characterised by hypoxia and chest radiograph changes. It is a serious post-operative complication, associated with considerable mortality and morbidity. In addition to mechanical ventilation, remote organ insult could also trigger systemic respons...more>>
J Biomed Res 2017;31(3): .
ORIGINAL ARTICLES
Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis
Xu Hu,Linfei Jiang,Chenhui Tang,Yuehong Ju,Li Jiu,Yongyue Wei,Li Guo,Yang Zhao
Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants of ESR1 in association with breast cancer susceptibility. We performed a meta-ana...more>>
J Biomed Res 2017;31(3): .
Genetic variation of the PSCA gene (rs2294008) is not associated with the risk of prostate cancer
Il-Seok Lee,Sung Pil Seo,Yun Sok Ha,Pildu Jeong,Ho Won Kang,Won Tae Kim,YongJune Kim,Seok Joong Yun,Sang Cheol Lee,Wun-Jae Kim
Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids and highly expressed in the prostate, but there have been few reports on the relationship between rs2294008 of PSCA and prostate cancer in the literature. Therefore, we evaluated the association between r...more>>
J Biomed Res 2017;31(3): .
Ginkgol C17:1 inhibits tumor growth by blunting the EGF-PI3K/Akt signaling pathway
Yueying Li,Jun Liu,Xiaoming Yang,Yan Dong,Yali Liu,Min Chen
Ginkgol C17:1 has been shown to inhibit apoptosis and migration of cancer cells, but the underlying mechanisms are not fully elucidated. In this study, we explored whether the inhibitory effects of Ginkgol C17:1 were associated with epidermal growth factor receptor (EGFR) and PI3K/Akt signaling. The...more>>
J Biomed Res 2017;31(3): .
Modeling and validating three dimensional human normal cervix and cervical cancer tissues in vitro
Anna Karolina Zuk,Xuesong Wen,Stephen Dilworth,Dong Li,Lucy Ghali
The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies. The aim of this study was to engineer a functional 3-D in vitro model of normal and cancerous cervical tissue. Normal epithelial and immortalized cervical epithelial ca...more>>
J Biomed Res 2017;31(3): .
Insensitivity of PI3K/Akt/GSK3 signaling in peripheral blood mononuclear cells of age-related macular degeneration patients
Xunxian Liu,Zemin Yao
Our recent studies with cultured retinal pigment epithelium cells suggested that overexpression of interleukin 17 receptor C (IL-17RC), a phenomenon observed in peripheral blood and chorioretinal tissues with age-related macular degeneration (AMD), was associated with altered activation of phosphati...more>>
J Biomed Res 2017;31(3): .
Electromyography and Fos immunostaining study establish a possible functional link between trigeminal proprioception and the oculomotor system in rats
Houcheng Liang,Jingdong Zhang,Pifu Luo,Hongna Zhu,Ying Qiao,Anle Su,Ting Zhang
The objective of this study was to explore whether there was a functional link between trigeminal proprioception and the oculomotor system mediated through jaw muscle afferents. Electromyography (EMG) was undertaken of the levator palpebrae (LP) and superior rectus (SR), and Fos expression was detec...more>>
J Biomed Res 2017;31(3): .
Setting kinetics and mechanical properties of flax fibre reinforced glass ionomer restorative materials
Ensanya Ali Abou Neel,Anne M. Young
Regardless of the excellent properties of glass ionomer cements, their poor mechanical properties limit their applications to non-load bearing areas. This study aimed to investigate the effect of incorporated short, chopped and randomly distributed flax fibers (0, 0.5, 1, 2.5, 5 and 25 wt%) on setti...more>>
J Biomed Res 2017;31(3): .
CASE REPORT
Spindle cell carcinoma of the mandible: a case report
Long Xie,Heming Wu,Siyu Liu,Hongwei Li
Spindle cell carcinoma is a rare highly malignant squamous cell carcinoma. Here, we describe a case of a 74-yearold Chinese female who presented with a 2-week history of pain and swelling in the left retromolar region. Surgical resection and titanium plate prosthesis were performed and histological ...more>>
J Biomed Res 2017;31(3): .30.20140061
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Early Releases
  • 1Proteomic analysis of the dorsal spinal cord in the mouse model of spared nerve injury-induced neuropathic pain
  • 2Profiles of metabolic gene expression in the white adipose tissue, liver and hypothalamus in leptin knockout rats (LepΔI14/ΔI14)
  • 3Immune checkpoint inhibitors in cancer therapy
  • 4Thalamic paramagnetic iron by T2* relaxometry correlates with severity of multiple sclerosis
  • 5Farnesol inhibits development of caries by augmenting oxygen sensitivity and suppressing virulence-associated gene expression in Streptococcus mutans
  • 6Effects of Chemotherapeutic Agent Bendamustin for Non-Hodgkin Lymphoma on Spermatogenesis in Mouse
  • 7(+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines
  • 8Distinctive roles of Rac1 and Rab29 in LRRK2 mediatedmem-brane trafficking and neurite outgrowth
  • 9Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway
  • 10Fasudil Alleviates LPS-induced Lung Injury by Resorting Aqua-porin 5 Expression and Inhibiting Inflammation in Lung
  • 11Association between exposure to particulate matter during pregnancy and birthweight: a systematic review and a meta-analysis of birth cohort studies
  • 12Sample size re-estimation without un-blinding for time-to-event outcomes in oncology clinical trials
  • 13Cost and value in medical education: the role of statistical process control
  • 14Moringa oleifera-based diet protects against nickel-induced hepatotoxicity in rats
  • 15Effects of leptin on femoral fracture in rats
  • 16Safety, immunogenicity, and cross-species protection of a plasmid DNA encoding Plasmodium falciparum SERA5 polypeptide, microbial epitopes and chemokine genes in mice and olive baboons
  • 17Synthetic plasma and silicon tubular harness-based pure biological transistor amplifier circuit
  • 18Herpes zoster in breast cancer: a case report
  • 19The pleiotropic vasoprotective functions of high density lipoproteins (HDL)
  • 20Detection of small bowel tumor in wireless capsule endoscopy images using an adaptive neuro-fuzzy inference system
  • 21Non-alcoholic fatty liver disease-a chronic disease of the 21st century
  • 22Re-evaluating the role of epithelial-mesenchymal-transition in cancer progression
  • 23Host-guest interaction of β-cyclodextrin with isomeric ursolic acid and oleanolic acid: physicochemical characterization and molecular modeling study
  • 24The effect of sunblock against oxidative stress in farmers: a pilot study
  • 25Nighttime snacking was associated with the risk of obesity and hyperglycemia in adults: a cross-sectional survey from chinese adult teachers
  • 26Aggf1 attenuates hepatic inflammation and activation of hepatic stellate cells by repressing Ccl2 transcription
  • 27Γ-Aminobutyric acid promotes methionine-choline deficient diet-induced nonalcoholic steatohepatitis
  • 28Acute-on-chronic liver failure: recent update
  • 29Exosomes and their role in the micro-/macro-environment: a comprehensive review
  • 30Oxidized phospholipids and lipoprotein-associated phospholipase A2 as important determinants of Lp(a) functionality and pathophysiological role
  • 31Monitoring cerebral ischemia during cerebrovascular surgery
  • 32Complex role of autophagy in regulation of hepatic lipid and lipoprotein metabolism
  • 33Focal Ischemia in Hippocampus Causes Deficits in Local Field Potential and Synaptic Plasticity
  • 34Clinical features of multiple myeloma patients with isolated extramedullary relapse
  • 35Low-dose radiation stimulates CD4 T-cell activation through enhancing MHC-II expression
  • 36Pathological Significance and Regulatory Mechanism of Abnormal High Expression of Lymphotoxin β Receptor in T cells of Patients with Systemic Lupus Erythematosus
  • 37Rapamycin reverses connexin 43 impairment in human herpes simplex virus-1 viral myocarditis
Newsletters
  • The Journal of Biomedical Research is indexed in ESCI
  • The Journal of Biomedical Research editorial team presents the journal at Thomson Reuters in Beijing
  • The Journal of Biomedical Research now indexed for PubMed and available at PubMed Central
  • MSC workshop was successfully held at NJMU
  • Scientific Writing and Publishing Workshop by Editors from Nature Journals
  • Dr Zemin Yao visits the JBR editorial office
  • The fourth board meeting held at the Journal of Biomedical Research
  • The Journal of Biomedical Research has entered co-branding agreement with Ding Xiang Yuan, a web portal serving the biomedical community
  • Drs. Roger J Smales and Ganesh Sahoo join the Journal of Biomedical Research as associate editors
  • The Journal of Biomedical Research is now indexed in Chemical Abstracts
  • The Journal of Biomedical Research starts using Crosscheck to prevent plagiarism in scholarly publication
  • The Journal of Biomedical Research revamps its web portal
  • Dr. Joseph Michael Miano joins the editorial board of the Journal of Biomedical Research
Top Journal Content
  • Leishmania donovani whole cell antigen delivered with adjuvants protects against visceral leishmaniasis in vervet monkeys (Chlorocebus aethiops)(3618)
  • Epidural abscess after multiple lumbar punctures for labour epidural catheter placement(3078)
  • Sitagliptin, sitagliptin and metformin, or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats(2945)
  • Role of remote sensing, geographic bioinformatics system and bioinformatics in kala-azar epidemiology(2924)
  • The expression and localization of a novel protein phosphatase inhibitor 2810408A11Rik in mouse testis and sperm(2911)
  • Effects of lysed Enterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model(2893)
  • Induced pluripotent stem cells are induced pluripotent stem cell-like cells(2822)
  • Apparent diffusion coefficient in normal and abnormal pattern of intervertebral lumbar discs: initial experience(2808)
  • UVB suppresses PTEN expression by upregulating miR-141 in HaCaT cells(2806)
  • Flotillin-2 is an acrosome-related protein involved in mouse spermiogenesis(2702)
  • Current perspectives of nanoparticles in medical and dental biomaterials(2663)
  • Single-dose and multiple-dose pharmacokinetics of zaltoprofen after oral administration in healthy Chinese volunteers(2627)
  • Clostridium difficile infections in China(2552)
  • Dual therapy of rosiglitazone/pioglitazone with glimepiride on diabetic nephropathy in experimentally induced type 2 diabetes rats(2463)
  • Atrial fibrillation(2355)
  • Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium(2314)
  • Lipoprotein metabolism in nonalcoholic fatty liver disease(2303)
  • Effects of infusion of different fluids during controlled hypotension on gastric intramucosal pH and postoperative gastroenterological function(2236)
  • Anisocoria in a 10-month old girl in the immediate preoperative setting: can you proceed with surgery?(2134)
  • Mycobacterium tuberculosis using statistical coupling analysis of the esterase family proteins(2113)
  • Secondary metabolite credentials of Evolvulus alsinoides by high performance thin layer chromatography (HPTLC)(2105)
  • MiR-148a inhibits angiogenesis by targeting ERBB3(2084)
  • Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells(2082)
  • Fracture resistance of posterior teeth restored with modern restorative materials(2073)
  • Comparative domain modeling of human EGF-like module EMR2 and study of interaction of the fourth domain of EGF with chondroitin 4-sulphate(2043)
  • Reduction of G0 phase cells of colon cancer caco-2 cells may enhance 5-fluorouracil efficacy(2037)
  • Sinomenine reduces iNOS expression via inhibiting the T-bet IFN-γ pathway in experimental autoimmune encephalomyelitis in rats(1996)
  • The MDM2-p53 pathway revisited(1975)
  • Cryptosporidiosis-an overview(1935)
  • Successful conservative management with methotrexate and mifepristone of cervical pregnancy(1928)
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